• It is well known that

  2023-09-11

  

  It is well-known that neurosteroids such as testosterone and their metabolites endogenously modulate neural excitability in animals and humans. Testosterone has protective effects against seizures induced by KA and PTZ (Frye et al., 2001b; Reddy, 2004b). Estrogens, on the other hand, have proconvuls

• Researchers demonstrated that mitochondria are the main prod

  2023-09-11

  

  Researchers demonstrated that mitochondria are the main producers of ROS and are the most sensitive to the effects of ROS. Mitochondria-mediated apoptosis may not be limited to the role of cytochrome c in the activation of caspase-3 and ROS may provide an alternate mitochondrial signaling pathway (H

• Recently dairy proteins obtained from whey

  2023-09-11

  

  Recently, dairy proteins obtained from whey have received considerable attention for their antioxidant bioactivity (Bayram et al., 2008; Haraguchi et al., 2011; Zhang et al., 2012). Bovine whey proteins (WP) are widely used in various foods for their nutritional, health-promoting, and functional val

• We provide here direct evidences that AT receptors are

  2023-09-09

  

  We provide here direct evidences that AT1 receptors are active in ADSCs since Ang II induces intracellular Ca mobilization in these cells. Data obtained during the observation of Ca influxes led us to the search for the ADSCs subpopulation constantly expressing AT1 receptor. ADSCs are necessary for

• In addition to differential expression of AR

  2023-09-09

  

  In addition to differential expression of AR protein primarily in surgical specimens, genetic alterations involving the AR gene have been documented in human eicosapentaenoic acid sale cancer. Loss of heterozygosity at the AR locus was identified in all 3 informative cases of muscle-invasive bladder

• The SMN and SMN promoters are regulated by transcription fac

  2023-09-09

  

  The SMN1 and SMN2 promoters are regulated by transcription factors such as E26 transformation-specific domain containing protein (ELK-1) and cAMP response element-binding protein (CREB) 58, 59. Compared with WT animals, mice with SMA exhibit increased and decreased ELK-1 and CREB phosphorylation, re

• The rescue of the behavioral deficit

  2023-09-09

  

  The rescue of the behavioral deficit was associated with a significant reduction in the levels of both soluble and insoluble Aβ peptides and their deposition in the phospholipase inhibitor of the same animals. In search for the mechanism behind the reduced amyloidosis, we assessed APP metabolism. C

• br Impact of global AHR deficiency

  2023-09-09

  

  Impact of global AHR deficiency on diet-induced obesity Two subsequent studies in which AHR function was affected at the whole animal level corroborated the role of AHR in dietary obesity. Xu et al. [14] showed that on a high-fat diet, both AHR-deficient Ahr−/− and hemizygous Ahr+/− mice gained s

• Sodium Nitroprusside Nrf br AhR br Nrf and AhR

  2023-09-09

  

  Nrf2 AhR Nrf2 and AhR: friends or foes for energetic metabolism? Perspectives in carcinogenesis upon xenobiotic exposure Acknowledgements Introduction Integration of endogenous and exogenous signals via appropriate receptors is at the core of biological differentiation and adaptive r

• Ketogenic diets are more effective in promoting

  2023-09-09

  

  Ketogenic diets are more effective in promoting weight loss than conventional caloric restriction [26] however, their effect on hepatic glucose and lipid metabolism remains inconclusive. Blood glucose homeostasis is tightly regulated. In both mice and humans consuming KD, baseline blood glucose decr

• br Material and methods br Results br Discussion GRK

  2023-09-09

  

  Material and methods Results Discussion GRK2 activity has increasingly been shown to contribute to the progression of numerous diseases and organ dysfunction [5], [6]. For instance, a large body of work over the last two decades has identified GRK2 as a major regulator of cardiac dysfunctio

• In terms of the full length proteins

  2023-09-09

  

  In terms of the full-length proteins, it was noted early on that ACs have two cellular localizations: as integral proteins of the plasma membrane and as soluble proteins in the cytosol. Based on the distribution in mammalian sequences, it was initially proposed that subclass IIIa contains only membr

• In this study we make the first simultaneous recordings

  2023-09-09

  

  In this study, we make the first simultaneous recordings of elastase inhibitor release in multiple brain regions at a temporal resolution less than 1 s. One of the most striking findings is that acetylcholine release has a remarkably similar temporal profile in the mPFC and dHPC, suggesting a coord

• A variety of quinazoline or fused pyrimidine substituted dia

  2023-09-09

  

  A variety of quinazoline or fused pyrimidine-substituted diaminotriazoles showed sub-100nM inhibition of Axl (). Diaminotriazoles similarly substituted with quinolines, isoquinolines and benzothiazoles also showed potent Axl activity (data not shown), but generally exhibited potent cytotoxicity and

• For these reasons the role

  2023-09-09

  

  For these reasons, the role played by autophagy in environmental neurotoxicity is not always easily determinable. Indeed, although the neuroprotective role of autophagy has been shown by several studies, sometimes induction of autophagy was associate with deleterious effects (Glick et al., 2010, Sri

15537 records 293/1036 page Previous Next First page 上5页 291292293294295 下5页 Last page